Design of amphotericin B oral formulation for antifungal therapy
نویسندگان
چکیده
منابع مشابه
assessment of the effect of honey as a topical therapy for intra oral wound healing in rat.
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15 صفحه اولNanoDisk containing super aggregated amphotericin B: a high therapeutic index antifungal formulation with enhanced potency
OBJECTIVES NanoDisk-amphotericin B (ND-AMB) is a protein-phospholipid bioparticle containing a "super aggregate" form of antifungal AMB. While lipid-based formulations of AMB, including liposomal AMB (L-AMB), are safer than the deoxycholate (DOC) solubilized form (DOC-AMB), the potency of lipid-based formulations is attenuated. We have developed an AMB-based therapy that is both well tolerated ...
متن کاملIn vitro antifungal activities of amphotericin B and liposome-encapsulated amphotericin B.
The in vitro activities of liposome-encapsulated amphotericin B and free amphotericin B against Candida albicans 336 were comparable. Amphotericin B concentrations 12-fold and greater than 50-fold higher were required to kill the same organism when cholesterol and ergosterol were incorporated into the liposomes. The addition of cholesterol to liposomes caused a significant increase in the minim...
متن کاملProtective and antifungal properties of Nanodisk-Amphotericin B over commercially available Amphotericin B☆
Objective Amphotericin B (AMB), a potent antifungal agent, has been employed as topical and systemic therapy for sinonasal fungal infections. A novel formulation of nanodisc (ND) containing super aggregated AMB (ND-AMB) for the treatment of fungal infections has been recently developed to provide greater protection from AMB toxicity than current, clinically approved lipid-based formulations. Th...
متن کاملComparative in vitro antifungal activity of amphotericin B and amphotericin B methyl ester.
The in vitro antifungal activity of amphotericin B methyl ester (AME), a water-soluble derivative of amphotericin B, was compared to that of the parent compound against a variety of pathogenic and potentially pathogenic fungi. AME has a significant antifungal activity, but the activity of AME was slightly lower than that of amphotericin B. Among the yeast-like organisms, only the yeast cells of...
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ژورنال
عنوان ژورنال: Drug Delivery
سال: 2017
ISSN: 1071-7544,1521-0464
DOI: 10.1080/10717544.2016.1225852